(HealthDay)—Qualitative computed tomography (CT) features differ between sufferers with BRCA-mutant high-grade serous ovarian most cancers (HGSOC) and sufferers with BRCA wild-type HGSOC, in line with a research revealed within the November challenge of Radiology.
Stephanie Nougaret, M.D., Ph.D., from Memorial Sloan-Kettering Cancer Center in New York City, and colleagues evaluated associations between CT features, BRCA mutation status, cytoreductive consequence, and progression-free survival (PFS) amongst 108 patients with HGSOC (33 with BRCA-mutant and 75 with BRCA wild-type HGSOC) who underwent CT earlier than main debulking.
The researchers discovered that peritoneal illness (PD) sample, presence of PD in gastrohepatic ligament, mesenteric involvement, and supradiaphragmatic lymphadenopathy at CT have been related to BRCA mutation status. Clinical and CT features weren’t related to cytoreductive end result for sufferers with BRCA-mutant HGSOC. However, in BRCA wild-type HGSOC, presence of PD in lesser sac (odds ratio [OR], 2.four) and left higher quadrant (OR, 1.19), mesenteric involvement (OR, 7.1), and lymphadenopathy in supradiaphragmatic (OR, 2.83) and suprarenal para-aortic (OR, four.79) areas have been related to greater odds of incomplete cytoreduction. There was a considerably shorter PFS related to mesenteric involvement at CT for each sufferers with BRCA-mutant HGSOC (hazard ratio [HR], 26.7) and people with BRCA wild-type HGSOC (reader 1: HR, 2.42; reader 2: HR, 2.61).
“This information may be of value for pretreatment patient counseling and initial decision making regarding maximal upfront cytoreductive effort versus neoadjuvant chemotherapy,” write the authors.
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